Understanding how bacteria help Coxsackievirus infections
Bacterial-mediated enhancement of Coxsackievirus
This work explores how certain bacteria in the gut might help Coxsackievirus cause infections in both children and adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11128367 on NIH RePORTER |
What this research studies
Coxsackievirus is a common infection that can lead to serious conditions like heart inflammation, brain swelling, and hand, foot, and mouth disease. Currently, there are not many good ways to prevent or treat these infections. We have learned that Coxsackievirus might use certain bacteria in the body to grow and cause illness. This project aims to discover exactly which parts of these bacteria interact with the virus and how they help the virus become stronger and more stable.
Who could benefit from this research
Good fit: This foundational work is relevant for anyone, especially children and adults, who are susceptible to or have been affected by Coxsackievirus infections.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat Coxsackievirus infections by targeting the bacteria that help the virus.
How similar studies have performed: Preliminary findings suggest that bacteria can enhance Coxsackievirus infectivity and stability, but the exact mechanisms are still unclear and are the focus of this novel investigation.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Robinson, Christopher Michael — Indiana University Indianapolis
- Study coordinator: Robinson, Christopher Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.