Understanding how bacteria form biofilms and their impact on infections
cdG Signaling and Adhesion Deployment During Biofilm Initiation
This study is looking at how bacteria change from swimming freely to sticking together in clusters, which can cause long-lasting infections, and it aims to find ways to stop these clusters from forming, helping to create better treatments for infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11042225 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that control how bacteria transition from free-swimming to forming biofilms, which are clusters of bacteria that can lead to chronic infections. By studying how bacteria sense their environment and adhere to surfaces, the research aims to uncover the signaling pathways involved in biofilm formation. This knowledge could lead to the development of new therapies to prevent or treat infections caused by biofilms. The research will focus on a specific signaling system that is important for both pathogenic and non-pathogenic bacteria.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic infections linked to bacterial biofilms.
Not a fit: Patients with acute infections not related to biofilm formation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for chronic infections associated with bacterial biofilms.
How similar studies have performed: Other research has shown promising results in understanding bacterial signaling and biofilm formation, indicating that this approach has potential for success.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: O'toole, George a. — Dartmouth College
- Study coordinator: O'toole, George a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.