Understanding how bacteria exchange genes to become resistant to antibiotics
Macrorecombination in isolated cell pairs via natural genetic transformation
This study is looking at how the bacteria that cause pneumonia become resistant to antibiotics, using special technology to see how they share DNA with each other, which could help us find better ways to treat infections for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11125757 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the bacterium Streptococcus pneumoniae acquires antibiotic resistance through gene transfer. By utilizing microfluidics technology, the study aims to create small chambers that allow for the observation of macro-recombination events, where large segments of DNA are transferred between bacteria. This approach will help clarify how these resistant strains emerge and spread, potentially leading to new strategies for combating bacterial infections. Patients may benefit from improved treatment options as a result of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant strains of Streptococcus pneumoniae.
Not a fit: Patients with infections caused by non-bacterial pathogens or those not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for preventing and treating antibiotic-resistant bacterial infections.
How similar studies have performed: Other research has shown success in understanding gene transfer mechanisms in bacteria, but the specific focus on macro-recombination in this context is relatively novel.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Eddington, David — University of Illinois at Chicago
- Study coordinator: Eddington, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.