Understanding how bacteria evolve to resist antibiotics
Evolutionary Tradeoffs in Antibiotic Resistance
['FUNDING_OTHER'] · HARVARD MEDICAL SCHOOL · NIH-11011835
This study looks at how bacteria become resistant to antibiotics and why some survive better than others, with the hope that the findings will help create better treatments for infections that are hard to treat.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11011835 on ClinicalTrials.gov |
What this research studies
This research investigates how bacteria develop resistance to antibiotics through genetic mutations and environmental factors. By examining the evolutionary tradeoffs that influence bacterial survival, the study aims to uncover why some resistant strains thrive while others do not. The approach includes laboratory experiments and computational analyses to model bacterial evolution under various conditions. Patients may benefit from insights that could lead to more effective treatments for antibiotic-resistant infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating antibiotic-resistant infections, improving treatment outcomes for patients.
How similar studies have performed: Other research has shown success in understanding bacterial evolution and antibiotic resistance, indicating that this approach is grounded in established scientific inquiry.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAYM, MICHAEL — HARVARD MEDICAL SCHOOL
- Study coordinator: BAYM, MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: chronic infection