Understanding how bacteria evolve resistance to antibiotics
Mapping epistatic interactions in molecular evolution of antibiotic resistance
This study is looking at how bacteria become resistant to antibiotics and aims to find new ways to fight these tough germs, so people with infections can get better treatments that actually work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11082531 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which bacteria develop resistance to antibiotics, focusing on two main strategies: altering drug target enzymes and modifying antibiotic molecules. The team aims to map the evolution of a key enzyme called dihydrofolate reductase (DHFR) and develop new inhibitors that can effectively target resistant strains. Additionally, they plan to create innovative molecules known as beta-lactamase traps to combat bacteria that produce enzymes that deactivate common antibiotics. By understanding these processes, the research seeks to inform the development of more effective treatments for bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from bacterial infections that are resistant to current antibiotic treatments.
Not a fit: Patients with viral infections or those not affected by antibiotic-resistant bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that are effective against resistant bacterial strains.
How similar studies have performed: Previous research has shown promise in understanding antibiotic resistance mechanisms, but this approach to mapping epistatic interactions is relatively novel.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Toprak, Erdal — Ut Southwestern Medical Center
- Study coordinator: Toprak, Erdal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.