Understanding how bacteria evolve and exchange DNA
Investigating the Impact and Patterns of Homologous Recombination and Adaptive Evolution on Bacterial Genomes
This study looks at how bacteria change and adapt over time, especially how they share DNA and develop traits like resistance to antibiotics, which can help us find better ways to fight bacterial infections and keep people healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-10814784 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of evolution in bacterial populations, focusing on how DNA exchange and adaptive evolution influence their genomes. By examining the rates and patterns of homologous recombination, the study aims to clarify how bacteria adapt to environmental stresses and develop traits such as antibiotic resistance. The research employs genetic models and population genetics methodologies to analyze bacterial strains and their evolutionary dynamics. This knowledge is crucial for developing strategies to combat bacterial infections and improve public health.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals suffering from bacterial infections, especially those resistant to standard treatments.
Not a fit: Patients with viral infections or non-bacterial diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of bacterial infections, particularly those involving antibiotic resistance.
How similar studies have performed: Other research has shown success in understanding bacterial evolution and recombination, indicating that this approach is grounded in established scientific inquiry.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Bobay, Louis-Marie — North Carolina State University Raleigh
- Study coordinator: Bobay, Louis-Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.