Understanding how bacteria divide and separate their chromosomes
Coordination mechanisms between cell division and chromosome segregation in E. coli
This study is looking at how bacteria like E. coli divide and grow, with the goal of finding new ways to stop them from causing infections, which could help develop better treatments for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Knoxville NIH-funded |
| Lab location | 1 site (Knoxville, United States) |
| Project ID | NIH-10894928 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that control cell division in bacteria, specifically focusing on Escherichia coli. By examining the two distinct stages of bacterial cell division, the study aims to identify potential targets for new antibacterial agents that can inhibit this process. The research employs advanced 3D modeling and biological models to analyze the interactions of proteins involved in the division process, which are crucial for bacterial survival. The findings could lead to innovative treatments for bacterial infections by disrupting their ability to reproduce.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with bacterial infections that are resistant to current antibiotics.
Not a fit: Patients with viral infections or non-infectious diseases are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibacterial agents that effectively stop bacterial growth and treat infections.
How similar studies have performed: Other research has shown success in targeting bacterial cell division mechanisms, indicating that this approach has potential for significant advancements.
Where this research is happening
Knoxville, United States
- University of Tennessee Knoxville — Knoxville, United States (Active)
Researchers
- Principal investigator: Mannik, Jaan — University of Tennessee Knoxville
- Study coordinator: Mannik, Jaan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.