Understanding how bacteria develop resistance to antibiotics in different environments
Unraveling the Interplay Between Self-Organization and Antimicrobial Resistance Evolution Across Spatial Scales
This study is looking at how bacteria, like the one that causes cholera, become resistant to antibiotics by seeing how they grow and behave in different environments, which could help us find better ways to treat infections in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10990186 on NIH RePORTER |
What this research studies
This research investigates the evolution of antimicrobial resistance (AMR) in bacteria by examining how these microorganisms organize themselves in various spatial environments, such as biofilms and the gut. The study aims to track AMR evolution at a cellular level over time and across different structures using a model pathogen, Vibrio cholerae. By combining laboratory experiments with theoretical modeling, the researchers hope to uncover the rules governing AMR development and validate these findings in living organisms. This could lead to a better understanding of how AMR evolves in real-world settings, ultimately informing treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by bacteria or those who are not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for combating antibiotic resistance, enhancing treatment options for patients with bacterial infections.
How similar studies have performed: Previous research has shown promising results in understanding AMR through laboratory studies, but this approach of integrating spatial self-organization is relatively novel.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Hallatschek, Oskar — University of California Berkeley
- Study coordinator: Hallatschek, Oskar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.