Understanding how bacteria defend against viruses using specific proteins
OLD family nuclease function across diverse anti-phage defense systems
['FUNDING_R15'] · DAVIDSON COLLEGE · NIH-11041414
This study is looking at how some proteins in bacteria help them fight off viruses, which could lead to new ways to understand and use these defenses in medicine and technology.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DAVIDSON COLLEGE (nih funded) |
| Locations | 1 site (DAVIDSON, UNITED STATES) |
| Trial ID | NIH-11041414 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which certain proteins in bacteria help protect them from viruses known as bacteriophages. By studying two classes of proteins, the researchers aim to uncover how these proteins interact with DNA and contribute to the bacteria's defense systems. The approach involves biochemical techniques to analyze these interactions and the roles of associated proteins. This research could lead to a better understanding of bacterial resistance and potential applications in biotechnology and medicine.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by antibiotic-resistant bacteria, particularly those related to Burkholderia pseudomallei.
Not a fit: Patients with viral infections that do not involve bacterial co-infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of bacterial resistance mechanisms, potentially leading to new strategies for combating antibiotic-resistant infections.
How similar studies have performed: While the study of anti-phage defense systems is ongoing, the specific focus on OLD proteins represents a novel approach that has not been extensively tested in prior research.
Where this research is happening
DAVIDSON, UNITED STATES
- DAVIDSON COLLEGE — DAVIDSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THURTLE-SCHMIDT, BRYAN H — DAVIDSON COLLEGE
- Study coordinator: THURTLE-SCHMIDT, BRYAN H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.