Understanding how bacteria copy their DNA
Structure and Function of the Bacterial Primosome
This work helps us understand how bacteria make copies of their DNA, which could lead to new ways to fight infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11123170 on NIH RePORTER |
What this research studies
Our bodies are constantly fighting off bacteria, and this project looks closely at how these tiny invaders reproduce. We are studying a key process called DNA replication restart, which bacteria use to fix and copy their genetic material. By understanding the exact steps and structures involved, we hope to find new weak spots in bacteria. This knowledge could help us develop better antibiotics to treat infections and potentially inform strategies for fighting certain cancers, as DNA replication is also important in human cells.
Who could benefit from this research
Good fit: Patients with bacterial infections or those interested in the fundamental mechanisms of DNA replication relevant to cancer may find this research relevant.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions will not directly benefit from this foundational basic science research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new and more effective antibiotic treatments for bacterial infections and offer insights into cancer therapies.
How similar studies have performed: While the broad importance of DNA replication restart is known, the detailed mechanisms are poorly understood, making this a novel and fundamental exploration.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Keck, James L — University of Wisconsin-Madison
- Study coordinator: Keck, James L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.