Understanding how bacteria control their size and protein distribution
Official title: Mechanisms of cell-size control in Gram-negative bacteria
Funded at Stanford University · NIH-11080365 · Data updated 2026-11-12
This study looks at how certain bacteria grow and organize their proteins, which could help us understand and fight antibiotic-resistant infections, ultimately benefiting patients dealing with these tough bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $308,800 |
| NIH project number | 5R01GM149611-02 |
| Project ID | NIH-11080365 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals suffering from infections caused by antibiotic-resistant bacteria.
✕Less likely to help
Patients with infections caused by antibiotic-sensitive bacteria may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which Gram-negative bacteria manage their cell size and the distribution of proteins within their cell envelope. By combining experimental techniques like microscopy and genetic engineering with mathematical modeling, the study aims to reveal how environmental factors influence bacterial growth and protein allocation. Patients may benefit from insights gained into bacterial behavior, particularly in the context of antibiotic resistance, as understanding these mechanisms could lead to more effective treatments. The research focuses on the physiological processes that sustain bacterial life, which are crucial for developing strategies to combat antibiotic-resistant infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating antibiotic-resistant bacterial infections.
How similar studies have gone: Other research has shown success in understanding bacterial mechanisms, but this specific approach integrating mathematical modeling with experimental biology is relatively novel.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Cremer, Jonas B — Stanford University
- Study coordinator: Cremer, Jonas B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.