Understanding how bacteria control their genes and internal structure
Building a unified framework for understanding bacterial gene regulation and chromosomal architecture
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11158682
This work helps us learn how bacteria manage their internal processes, which is key to finding new ways to fight antibiotic-resistant infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11158682 on ClinicalTrials.gov |
What this research studies
Antibiotic-resistant bacteria are a growing global health concern, making it harder to treat common infections. To develop new treatments, we need to deeply understand how bacteria operate at a fundamental level. This project explores how bacteria regulate their genes and organize their internal structures, including their chromosomes. By mapping these complex networks, we aim to uncover the basic rules that govern bacterial behavior. This knowledge is essential for predicting how bacteria will act and for designing effective strategies to stop their growth or prevent them from causing disease.
Who could benefit from this research
Good fit: Patients who could benefit from future treatments for antibiotic-resistant bacterial infections are the ultimate focus of this foundational research.
Not a fit: Patients will not directly participate in this laboratory-based research, so there is no immediate benefit or harm from participation.
Why it matters
Potential benefit: If successful, this research could lead to entirely new strategies for developing medicines that target antibiotic-resistant bacteria, offering hope for patients with difficult-to-treat infections.
How similar studies have performed: Previous work by this laboratory and others has already shown that factors like chromosomal structure and epigenetic changes play a role in bacterial gene regulation, building a foundation for this deeper investigation.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FREDDOLINO, LYDIA PETRA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: FREDDOLINO, LYDIA PETRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.