Understanding how bacteria control gene expression to develop new antibiotics
Official title: Bacterial ribosome heterogeneity and gene expression
Funded at University of Louisville · NIH-11248163 · Data updated 2026-11-12
This study is looking at how differences in bacteria's ribosomes can change how they behave and respond to antibiotics, with the goal of finding new ways to create effective treatments for infections that are hard to treat.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $399,584 |
| NIH project number | 7R35GM150599-03 |
| Project ID | NIH-11248163 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients suffering from bacterial infections, particularly those caused by antibiotic-resistant strains, would be ideal candidates to benefit from this research.
✕Less likely to help
Patients with viral infections or those who do not have bacterial infections may not receive any benefit from this research.
What this research studies
This research investigates how variations in bacterial ribosomes affect gene expression, which is crucial for developing new antibiotics. The team will explore the role of ribosome heterogeneity in different bacterial species, focusing on how it influences the production of virulence factors and the effectiveness of antimicrobial drugs. By leveraging advanced genetic techniques, the researchers aim to identify new targets for antibiotic development that could help combat antibiotic-resistant infections. This work is essential as it addresses a significant gap in our understanding of bacterial behavior and drug resistance.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antibiotics that are effective against resistant bacterial infections.
How similar studies have gone: While the specific approach of examining ribosome heterogeneity is innovative, similar research has shown promise in identifying new antimicrobial targets.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Ramsey, Kathryn Mary — University of Louisville
- Study coordinator: Ramsey, Kathryn Mary
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.