Understanding how bacteria contribute to gum disease
Official title: Pathoadaptive Modulation of Porphyromonas gingivalis Lipopolysaccharide Structure and Function
Funded at University of Louisville · NIH-10857668 · Data updated 2026-11-12
This study is looking at how certain parts of bacteria might cause gum disease and how a specific molecule helps control these parts, with the hope that it will lead to better treatments for people suffering from periodontitis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $422,550 |
| NIH project number | 1R01DE033702-01 |
| Project ID | NIH-10857668 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from chronic periodontitis.
✕Less likely to help
Patients without chronic periodontitis or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of specific bacterial components in the development of periodontitis, a common inflammatory disease affecting the tissues that support teeth. The study focuses on how the structure and function of lipopolysaccharides from the bacteria Porphyromonas gingivalis are regulated by a signaling molecule called c-di-AMP. By analyzing the genetic and molecular mechanisms involved, the research aims to uncover how these interactions contribute to the progression of gum disease. Patients may benefit from insights that could lead to new treatments or preventive strategies for periodontitis.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for periodontitis, potentially reducing tooth loss and improving oral health.
How similar studies have gone: Previous research has shown promising results in understanding bacterial interactions in periodontal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Moradali, Fata — University of Louisville
- Study coordinator: Moradali, Fata
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.