Understanding how bacteria communicate in infections
Decoding interspecies signaling networks and the biogeography of polymicrobial infections
['FUNDING_OTHER'] · TRUSTEES OF INDIANA UNIVERSITY · NIH-10862807
This study is looking at how different types of bacteria interact with each other in the lungs of people with cystic fibrosis, especially focusing on a stubborn bacteria called Pseudomonas aeruginosa, to find better ways to treat infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TRUSTEES OF INDIANA UNIVERSITY (nih funded) |
| Locations | 1 site (BLOOMINGTON, UNITED STATES) |
| Trial ID | NIH-10862807 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between different bacterial species in polymicrobial infections, particularly in the lungs of cystic fibrosis patients. By using advanced 3-D imaging techniques, the team aims to visualize and decode the communication networks among bacteria in their natural environments. The study focuses on the opportunistic pathogen Pseudomonas aeruginosa, which is known to persist in chronic infections despite antibiotic treatment. Through this work, researchers hope to uncover new insights into how these bacterial communities behave and adapt, which could lead to improved treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include cystic fibrosis patients who experience chronic lung infections.
Not a fit: Patients with acute infections or those not affected by polymicrobial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for chronic infections, particularly in cystic fibrosis patients.
How similar studies have performed: Previous research has shown promising results in understanding bacterial communication in similar contexts, suggesting potential for breakthroughs in treatment.
Where this research is happening
BLOOMINGTON, UNITED STATES
- TRUSTEES OF INDIANA UNIVERSITY — BLOOMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIMOLI, DOMINIQUE — TRUSTEES OF INDIANA UNIVERSITY
- Study coordinator: LIMOLI, DOMINIQUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: CF infection