Understanding how bacteria cause infections in urinary catheters to develop new treatments
Defining Host-pathogen Interactions in CAUTI to Guide Novel Drug Development
['FUNDING_CAREER'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10987027
This study is looking at how a specific enzyme from a type of bacteria affects urinary tract infections in people who use catheters for a long time, with the goal of finding better ways to prevent and treat these infections.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10987027 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between bacteria and urinary catheters, focusing on catheter-associated urinary tract infections (CAUTIs). It aims to understand how the enzyme urease produced by Staphylococcus aureus contributes to these infections, particularly in patients with chronic indwelling catheters. By analyzing the genetic and functional roles of urease, the research seeks to identify new strategies for preventing and treating CAUTIs, which are common and serious complications for catheterized patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who require chronic indwelling urinary catheters due to conditions like incontinence or neurogenic bladder.
Not a fit: Patients who do not use urinary catheters or have acute, short-term catheterization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel treatments that significantly reduce the incidence of infections associated with urinary catheters.
How similar studies have performed: Previous research has shown promising results in understanding bacterial infections related to medical devices, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALKER, JENNIFER NICOLE — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: WALKER, JENNIFER NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.