Understanding how bacteria cause ear infections in children
Determinants of H. influenzae Virulence in Otitis Media
This research explores new ways to fight common ear infections in children, especially those caused by a specific type of bacteria that is becoming harder to treat with current antibiotics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11062505 on NIH RePORTER |
What this research studies
Many children experience ear infections, and while vaccines have helped with some types, a specific bacteria called NTHI is now a leading cause. These infections often involve bacteria forming protective layers called biofilms, which make them very difficult for standard antibiotics to reach and kill. Unfortunately, using broad-spectrum antibiotics can also cause side effects like rashes and diarrhea, and may even disrupt a child's gut health. This project aims to find better ways to combine the body's natural defenses (antibodies) with more targeted antibiotic use to overcome these challenges.
Who could benefit from this research
Good fit: This research is most relevant to children, particularly those aged 0-11 years, who frequently suffer from ear infections caused by Haemophilus influenzae.
Not a fit: Patients whose ear infections are caused by different types of bacteria or who do not experience recurrent infections may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more effective treatments for ear infections, reduce the need for broad-spectrum antibiotics, and prevent long-term health issues related to antibiotic use in children.
How similar studies have performed: While the importance of biofilms in ear infections is recognized, this project explores novel approaches by considering a newly identified bacterial state and combining antibodies with antibiotics in new ways.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Goodman, Steven D — Research Inst Nationwide Children's Hosp
- Study coordinator: Goodman, Steven D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.