Understanding how bacteria build their protein-making machines
Dynamics of the Bacterial Ribosome and Proteome
This study is looking at how bacteria build their protein-making machines called ribosomes, which could help us find new ways to develop antibiotics that fight bacterial infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11091320 on NIH RePORTER |
What this research studies
This research investigates the intricate process of ribosome assembly in bacteria, which is crucial for protein synthesis. By using advanced techniques like cryo-electron microscopy and mass spectrometry, the study aims to uncover how ribosomes are formed and the role of various assembly factors in this process. The research will also explore how ribosome assembly can be inhibited, potentially leading to new therapeutic strategies. Patients may benefit from insights gained into bacterial function and antibiotic development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with bacterial infections or those interested in the mechanisms of antibiotic resistance.
Not a fit: Patients with viral infections or non-bacterial diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bacterial infections by targeting ribosome assembly.
How similar studies have performed: Other research has shown success in understanding ribosome function and assembly, indicating that this approach is built on established scientific principles.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Williamson, James R — Scripps Research Institute, the
- Study coordinator: Williamson, James R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.