Understanding how bacteria build their protective outer layers
Spatiotemporal regulation of bacterial cell envelope assembly
This study is looking at how certain bacteria build their protective outer layers, focusing on a special protein that helps attach important pieces to the wall, which could help us find new ways to fight bacterial infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10906814 on NIH RePORTER |
What this research studies
This research investigates the complex processes by which bacterial cells, particularly Gram-positive bacteria, assemble their cell envelopes during growth and division. By using advanced microscopy techniques, the study aims to uncover the mechanisms that regulate the incorporation of surface proteins into the cell wall, which are crucial for bacterial function and survival. The research focuses on a specific protein called sortase A and its role in attaching these proteins to the cell wall, as well as the influence of other components like lipoteichoic acid. This work could provide insights into bacterial behavior and potentially lead to new strategies for combating bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by Gram-positive bacteria, such as Staphylococcus aureus.
Not a fit: Patients with infections caused by Gram-negative bacteria or those not affected by bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bacterial infections by targeting the mechanisms that allow bacteria to thrive.
How similar studies have performed: Other research has shown success in understanding bacterial cell processes, but this specific approach to studying cell envelope assembly is relatively novel.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Yu, Wenqi — University of South Florida
- Study coordinator: Yu, Wenqi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.