Understanding how bacteria build their protective outer layers
Targeting Membrane Transport Steps in Cell Envelope Assembly
['FUNDING_R01'] · HARVARD UNIVERSITY · NIH-10824312
This study is looking at how certain bacteria, like those that cause tuberculosis, protect themselves from antibiotics and how we can find new ways to fight these tough infections by understanding the proteins that help build their protective outer layers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD UNIVERSITY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10824312 on ClinicalTrials.gov |
What this research studies
This research investigates the complex cell envelopes of Gram-negative bacteria and mycobacterium tuberculosis, which are crucial for their survival and resistance to antibiotics. By focusing on three key protein transporters involved in cell envelope assembly, the research aims to uncover how these transporters function and how they can be targeted. The approach includes biochemical and structural studies to analyze the transport mechanisms and the role of inhibitors. The ultimate goal is to develop new therapies that can effectively treat infections caused by these resistant bacteria.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by Gram-negative bacteria or mycobacterium tuberculosis.
Not a fit: Patients with infections caused by Gram-positive bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for antibiotic-resistant infections.
How similar studies have performed: Previous research has shown promise in targeting bacterial transport mechanisms, indicating potential for success in this area.
Where this research is happening
CAMBRIDGE, UNITED STATES
- HARVARD UNIVERSITY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAHNE, DANIEL — HARVARD UNIVERSITY
- Study coordinator: KAHNE, DANIEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.