Understanding how bacteria behave at the single-cell level
ILLUMINATING CELLULAR INDIVIDUALITY THROUGH BACTERIOPHAGE INFECTION
This study looks at how genetically identical bacteria act differently when they get infected by viruses, which could help us understand why some bacteria become resistant to antibiotics and how they behave in different situations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-10873988 on NIH RePORTER |
What this research studies
This research investigates the unpredictable behavior of genetically identical bacteria when exposed to bacteriophage infection. By examining how these cells respond individually, the study aims to uncover the underlying mechanisms that contribute to their diverse behaviors, such as antibiotic resistance. The approach involves analyzing gene expression and signaling pathways at the single-cell level to identify deterministic factors that influence cellular fate. This could lead to a better understanding of bacterial behavior in various environments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from bacterial infections, particularly those caused by E. coli.
Not a fit: Patients with viral infections or those not affected by bacterial diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of bacterial behavior, potentially leading to improved treatments for bacterial infections.
How similar studies have performed: Previous research has shown success in understanding cellular behavior through similar approaches, indicating that this study builds on established concepts in the field.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Golding, Ido — University of Illinois at Urbana-Champaign
- Study coordinator: Golding, Ido
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.