Understanding how bacteria become resistant to antibiotics
Official title: Bacterial Reprogramming that Contributes to Antibiotic Persistence toward Topoisomerase Inhibitors
Funded at University of Connecticut Sch of Med/dnt · NIH-11092914 · Data updated 2026-11-12
This study is looking at how some tough bacteria can survive antibiotics by acting differently, and it aims to find better ways to help antibiotics work against these bacteria, which could lead to improved treatments for infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | May 21, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $489,677 |
| NIH project number | 5R01AI167886-02 |
| Project ID | NIH-11092914 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant bacteria.
✕Less likely to help
Patients with infections caused by bacteria that are not resistant to antibiotics may not benefit from this research.
What this research studies
This research investigates how certain bacteria, specifically Escherichia coli and Pseudomonas aeruginosa, can survive antibiotic treatments by temporarily changing their behavior. The study focuses on bacteria that are in slow-growing states, making them harder to kill with standard antibiotics. By exploring ways to enhance the effectiveness of existing and new treatments, the research aims to reduce the ability of these bacteria to persist and develop resistance. Patients may benefit from improved antibiotic therapies that can more effectively treat infections caused by these resistant bacteria.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for antibiotic-resistant infections, potentially saving lives.
How similar studies have gone: Other research has shown promise in developing strategies to combat antibiotic resistance, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Mok, Wendy W.k. — University of Connecticut Sch of Med/dnt
- Study coordinator: Mok, Wendy W.k.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.