Understanding how bacteria and the immune system interact in tuberculosis transmission
Bacteria and Host in TB Transmission
This study looks at how tuberculosis spreads in homes by examining different types of the bacteria and how they interact with our immune system, especially in places like Brazil and Uganda, to find better ways to stop the disease from spreading.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10813834 on NIH RePORTER |
What this research studies
This research investigates how tuberculosis (TB) spreads within households, focusing on the interactions between different strains of the bacteria Mycobacterium tuberculosis and the host's immune response. By studying both past and current cases in Brazil and Uganda, the research aims to uncover the dynamics of TB transmission, particularly in mixed infections where multiple strains are present. The approach includes analyzing how these bacterial strains survive and how they affect the immune system's ability to respond, which could lead to new strategies for controlling TB spread.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living in households with confirmed tuberculosis cases, particularly in Brazil and Uganda.
Not a fit: Patients who do not have tuberculosis or are not in close contact with infected individuals may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for preventing and treating tuberculosis, ultimately reducing its transmission and impact on public health.
How similar studies have performed: Previous research has shown that understanding bacterial interactions and host responses can significantly enhance our knowledge of infectious disease transmission, suggesting potential for success in this approach.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Alland, David — Rutgers Biomedical and Health Sciences
- Study coordinator: Alland, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.