Understanding how bacteria and the immune system affect tuberculosis progression
Bacterial and host determinants of progression, manifestations and consequences of TB
['FUNDING_OTHER'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-10874595
This study is looking at what makes some people develop tuberculosis (TB) after being exposed to it, focusing on different types of TB bacteria and how each person's immune system responds, and it's for anyone who has been in close contact with TB patients in Uganda and Brazil.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10874595 on ClinicalTrials.gov |
What this research studies
This research investigates the factors that influence the progression of tuberculosis (TB) from infection to disease. It focuses on how different strains of the TB bacteria and variations in the host's immune response can affect the likelihood of developing TB after exposure. By studying individuals who have been in close contact with TB patients, the research aims to identify specific bacterial characteristics and immune signatures that predict disease outcomes. The study will involve both prospective and retrospective cohorts in Uganda and Brazil to gather comprehensive data on TB progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been in close contact with someone diagnosed with tuberculosis.
Not a fit: Patients who are not at risk of tuberculosis exposure or those who have already been diagnosed and treated for TB may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and preventing the progression of tuberculosis in at-risk populations.
How similar studies have performed: Previous research has shown success in identifying immune signatures that correlate with TB progression, indicating that this approach has potential for meaningful insights.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIETZE, REYNALDO — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: DIETZE, REYNALDO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
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