Understanding how bacteria affect tuberculosis treatment responses
Bacterial Determinants of Treatment Response in Mycobacteria Tuberculosis
['FUNDING_OTHER'] · HARVARD MEDICAL SCHOOL · NIH-10595535
This study is looking at how certain genes in Mycobacteria tuberculosis (the bacteria that causes TB) affect how well treatments work, especially for those with drug-resistant TB, and it aims to help doctors find better ways to diagnose and treat patients like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10595535 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that influence how Mycobacteria tuberculosis (MTB) responds to treatment, particularly focusing on drug resistance. By utilizing advanced molecular diagnostics, the study aims to identify specific genetic markers associated with treatment failure and drug resistance. Patients will be involved in providing clinical samples, which will help researchers develop more effective diagnostic tools and treatment strategies. The ultimate goal is to enhance the accuracy of tuberculosis diagnoses and improve treatment outcomes for patients with drug-resistant TB.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with tuberculosis, especially those suspected of having drug-resistant forms of the disease.
Not a fit: Patients who do not have tuberculosis or those with non-infectious diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnostics and personalized treatment plans for tuberculosis patients, particularly those with drug-resistant strains.
How similar studies have performed: Previous research has shown promise in using molecular diagnostics for tuberculosis, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MURRAY, MEGAN B — HARVARD MEDICAL SCHOOL
- Study coordinator: MURRAY, MEGAN B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Communicable Diseases, Infectious Disease Pathway, Infectious Diseases