Understanding how bacteria affect tuberculosis treatment response
Investigating bacterial contributions to TB treatment response: a focus on in-host pathogen dynamics
This study is looking at how bacteria behave in your body while you're being treated for tuberculosis (TB) to see how these changes might affect how well the treatment works, with the goal of finding better ways to help you get cured.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10899541 on NIH RePORTER |
What this research studies
This research investigates the dynamics of bacteria within the body during tuberculosis (TB) treatment. It aims to identify how changes in bacterial populations can influence treatment outcomes, particularly focusing on genetic changes that may lead to drug tolerance or resistance. By studying these in-host pathogen dynamics over time, the research seeks to improve monitoring methods for TB treatment and enhance understanding of how to achieve a cure. Patients may be monitored for their response to treatment using advanced genomic techniques.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with tuberculosis who are undergoing treatment.
Not a fit: Patients who do not have tuberculosis or those who are not currently receiving treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective monitoring and treatment strategies for tuberculosis, potentially improving cure rates.
How similar studies have performed: Previous research has shown promise in understanding pathogen dynamics in other infectious diseases, suggesting potential for success in this novel approach to tuberculosis treatment.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Farhat, Maha — Harvard Medical School
- Study coordinator: Farhat, Maha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.