Understanding how bacteria affect tuberculosis treatment outcomes
Investigating bacterial contributions to TB treatment response: a focus on in-host pathogen dynamics
This study is looking at how the bacteria causing tuberculosis change while you're being treated and how those changes affect how well the treatment works, with the goal of finding better ways to help people with TB.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10950546 on NIH RePORTER |
What this research studies
This research investigates how bacterial populations within the body change during tuberculosis (TB) treatment and how these changes impact treatment response. By analyzing the genetic variations of the bacteria over time, the study aims to identify factors that contribute to treatment success or failure. Patients will be monitored for their response to TB therapy, and the research will utilize advanced techniques like whole genome sequencing to gain insights into the dynamics of the infection. This approach could lead to more personalized treatment strategies for TB patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis who are undergoing antibiotic treatment.
Not a fit: Patients who have not been diagnosed with tuberculosis or those who are not receiving treatment for the infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for tuberculosis, potentially increasing cure rates.
How similar studies have performed: Previous research has shown promise in understanding pathogen dynamics in other infections, suggesting that this approach could yield valuable insights for tuberculosis treatment as well.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Farhat, Maha — Harvard Medical School
- Study coordinator: Farhat, Maha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.