Understanding how bacteria adapt to acid in the mouth
Official title: Investigating Membrane Alterations as a Mechanism of Acid Tolerance in Cariogenic Bacteria
Funded at Oregon Health & Science University · NIH-11103285 · Data updated 2026-11-12
This study looks at how cavity-causing bacteria in your mouth change to survive in acidic conditions, with the goal of finding new ways to prevent cavities that go beyond just using fluoride.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00DE029228-05 |
| Project ID | NIH-11103285 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at high risk for dental caries, such as those with a history of cavities or poor oral hygiene.
✕Less likely to help
Patients who do not have issues with dental caries or those with no significant risk factors for cavities may not benefit from this research.
What this research studies
This research investigates how certain bacteria in the mouth, particularly those that cause cavities, adapt to acidic environments. It focuses on the changes in their cell membranes that help them survive and thrive despite the presence of acid. By studying these adaptations, the research aims to uncover new strategies for preventing dental caries beyond traditional fluoride treatments. The approach includes examining the responses of various bacterial species to acid stress in both isolated and community settings.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for preventing dental caries, improving oral health for many individuals.
How similar studies have gone: Other research has shown promise in understanding bacterial adaptations to environmental stresses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Baker, Jonathon — Oregon Health & Science University
- Study coordinator: Baker, Jonathon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.