Understanding how B7-H3 contributes to neuroblastoma spread and immune evasion
Official title: Defining the mechanisms of B7-H3 overexpression and role in neuroblastoma metastasis and immune evasion
Funded at University of Pennsylvania · NIH-10930001 · Data updated 2026-11-12
This study is looking at a protein called B7-H3 that is often found in high amounts in neuroblastoma, a cancer that mainly affects kids, to see how it helps the cancer grow and avoid the immune system, with the goal of finding new ways to treat patients better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $36,651 |
| NIH project number | 5F31CA284708-02 |
| Project ID | NIH-10930001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with high-risk neuroblastoma, particularly those who have not responded well to existing therapies.
✕Less likely to help
Patients with low-risk neuroblastoma or those who have already achieved remission may not benefit from this research.
What this research studies
This research investigates the role of B7-H3, a protein that is often overexpressed in neuroblastoma, a type of cancer that primarily affects children. The study aims to understand how B7-H3 contributes to the cancer's ability to spread and evade the immune system. By exploring the mechanisms behind B7-H3's function, researchers hope to identify new therapeutic targets that could improve treatment outcomes for patients. The approach includes preclinical testing of immunotherapeutic strategies, such as CAR-T cells and antibody-drug conjugates, aimed at targeting B7-H3.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for neuroblastoma, potentially improving survival rates and reducing side effects.
How similar studies have gone: Previous research has shown promise in targeting B7-H3 in other cancers, suggesting that this approach may be effective in neuroblastoma as well.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Wingrove, Catherine Leona-Grace — University of Pennsylvania
- Study coordinator: Wingrove, Catherine Leona-Grace
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.