Understanding how B cells respond during influenza infections
Official title: Extrafollicular B cell response regulation during influenza infection
Funded at Johns Hopkins University · NIH-11111330 · Data updated 2026-11-12
This study is looking at how certain immune cells called B cells respond to the flu virus, with the goal of finding ways to make vaccines and treatments for the flu even better, which could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 10, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $596,636 |
| NIH project number | 5R01AI184867-02 |
| Project ID | NIH-11111330 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of influenza infection, including those with weakened immune systems or chronic health conditions.
✕Less likely to help
Patients who are not at risk for influenza or those who have already been vaccinated may not receive direct benefits from this research.
What this research studies
This research investigates the role of B cells in the immune response to influenza infections, focusing on how these cells are activated and differentiate to produce antibodies. The study aims to understand the signals that influence B cell behavior during infection, particularly the roles of specific pathways in their activation and proliferation. By examining the interactions between B cells and other immune signals, the research seeks to uncover mechanisms that could enhance the effectiveness of vaccines and treatments for influenza. Patients may benefit from insights that could lead to improved vaccine strategies and therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and treatments for influenza, enhancing patient immunity.
How similar studies have gone: Previous research has shown promising results in understanding B cell responses in other infections, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Baumgarth, Nicole — Johns Hopkins University
- Study coordinator: Baumgarth, Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.