Understanding how B cells in tonsil tissues respond to metabolic changes in obstructive sleep apnea patients
Official title: Decoding Spatially Resolved Single Cell Metabolic Trajectory of Tonsil Tissues and Organoids
Funded at Georgia Institute of Technology · NIH-10904799 · Data updated 2026-11-12
This study is looking at how certain immune cells called B cells work in the tonsils of people with and without obstructive sleep apnea (OSA) to see if there are any differences that might make it harder for them to fight off infections like the flu.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $236,100 |
| NIH project number | 5R21AI173900-02 |
| Project ID | NIH-10904799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with obstructive sleep apnea, particularly those experiencing frequent infections.
✕Less likely to help
Patients without obstructive sleep apnea or those not experiencing immune deficiencies may not benefit from this research.
What this research studies
This research investigates the metabolic processes of B cells in the germinal centers of tonsil tissues from patients with and without obstructive sleep apnea (OSA). By utilizing a novel spatially resolved metabolic profiling framework, the study aims to map the metabolic trajectories of B cell subsets at a single-cell level. This approach will help identify any metabolic defects that may contribute to weakened immune responses in OSA patients, particularly in relation to influenza infections. The findings could provide insights into how B cell development is affected by metabolic conditions associated with OSA.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of immune deficiencies in patients with obstructive sleep apnea.
How similar studies have gone: While the specific approach of spatially resolved metabolic profiling is relatively novel, similar studies have shown success in understanding immune responses in other contexts.
Where this research is happening
-
Georgia Institute of Technology
Atlanta, United States Active
Researchers
- Principal investigator: Coskun, Ahmet F. — Georgia Institute of Technology
- Study coordinator: Coskun, Ahmet F.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.