Understanding how B-cells improve their ability to fight infections
Official title: Project 2: Affinity Maturation of the B-cell Repertoire
Funded at Boston Children's Hospital · NIH-11290942 · Data updated 2026-11-12
This study looks at how a special type of immune cell called B-cells gets better at fighting off germs over time, which could help us create better vaccines and treatments for everyone.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $379,959 |
| NIH project number | 5P01AI089618-13 |
| Project ID | NIH-11290942 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with immune system deficiencies or those seeking enhanced vaccine responses.
✕Less likely to help
Patients with fully functioning immune systems and no history of infections may not receive direct benefits from this research.
What this research studies
This research investigates the process by which B-cells, a type of immune cell, enhance their ability to recognize and respond to pathogens over time. By examining the maturation of the B-cell repertoire, the study aims to uncover mechanisms that could lead to more effective vaccines and therapies. Patients may benefit from insights gained into how their immune systems can be trained to better combat infections. The research employs advanced immunological techniques to analyze B-cell responses in various contexts.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and therapies that enhance the immune response in patients.
How similar studies have gone: Previous research has shown promising results in understanding B-cell maturation and its implications for vaccine development.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Kelsoe, Garnett H — Boston Children's Hospital
- Study coordinator: Kelsoe, Garnett H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.