Understanding how B cells help T cells fight tumors effectively
Official title: Mechanism underlying how host B cells empower adoptively transferred Th17 cells with durable tumor immunity
Funded at Emory University · NIH-11054557 · Data updated 2026-11-12
This study is looking at how certain immune cells, called B cells, can help another type of immune cell, Th17 cells, work better together to fight tough cancers, with the goal of finding new ways to improve treatment for patients facing these challenges.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 5F31CA281258-02 |
| Project ID | NIH-11054557 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with aggressive malignancies who have not responded to existing treatments or are at high risk of relapse.
✕Less likely to help
Patients with non-aggressive tumors or those who are not eligible for adoptive T cell transfer therapies may not benefit from this research.
What this research studies
This research investigates how certain immune cells, specifically B cells, can enhance the effectiveness of T cells in fighting aggressive tumors. The approach focuses on a type of T cell known as Th17, which has shown promise in providing long-lasting immunity against cancer. By studying the interactions between Th17 cells and B cells, the researchers aim to develop a more effective treatment strategy that could lead to improved outcomes for patients with difficult-to-treat cancers. The methodology involves examining the roles of specific proteins and signals that support the cooperation between these immune cells.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer therapies that provide long-lasting immunity and reduce the chances of tumor relapse.
How similar studies have gone: Previous research has shown promising results with similar approaches, particularly in enhancing T cell persistence and effectiveness in cancer treatment.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Cole, Anna Camille Elyse — Emory University
- Study coordinator: Cole, Anna Camille Elyse
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.