Understanding how B cells help HIV-1 spread and establish a hidden reservoir
Elucidating the role of B cell mediated trans infection in the establishment of the latent HIV-1 reservoir
This study is looking at how certain immune cells called B cells can pass the HIV-1 virus to other immune cells, which might help explain why the virus can stick around in the body even when people are on treatment, and it could lead to new ways to fight the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10890130 on NIH RePORTER |
What this research studies
This research investigates the role of B cells in the transmission of HIV-1, focusing on how they can transfer the virus to other immune cells, particularly CD4+ T cells. The study aims to provide direct evidence of this process in living organisms, which has been lacking in previous research. By examining the unique capabilities of B cells compared to other immune cells, the research seeks to uncover mechanisms that contribute to the persistence of HIV-1 in the body, even in the presence of antiretroviral therapy. This could lead to new insights into HIV-1 pathogenesis and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV, particularly those who are not on antiretroviral therapy or those who are classified as nonprogressors.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for targeting and eliminating the latent HIV-1 reservoir, potentially benefiting individuals living with HIV.
How similar studies have performed: While the role of B cells in HIV-1 transmission has been studied, this specific investigation into their unique capabilities and the establishment of latent reservoirs is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Sluis-Cremer, Nicolas Paul — University of Pittsburgh at Pittsburgh
- Study coordinator: Sluis-Cremer, Nicolas Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.