Understanding how B cells function in health and disease
Official title: Unraveling the functional diversity of B cells in health and disease
Funded at University of Chicago · NIH-10898058 · Data updated 2026-11-12
This study is looking at how B cells, which help our immune system fight infections and manage allergies, behave in different health situations, and it’s for anyone interested in understanding how these cells work to improve treatments for conditions like autoimmune diseases and inflammatory bowel disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 2, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $492,000 |
| NIH project number | 5DP2AI177884-02 |
| Project ID | NIH-10898058 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases, allergies, or infections where B cell activity is a significant factor.
✕Less likely to help
Patients without any B cell-related conditions or those who do not have a significant immune response may not benefit from this research.
What this research studies
This research investigates the diverse roles of B cells, which are crucial for our immune response, in conditions like infections, autoimmune diseases, and allergies. By utilizing advanced techniques such as single-cell RNA sequencing and spatial transcriptomics, the study aims to analyze the behavior and characteristics of individual B cells in various biological contexts. The researchers will develop new computational tools to better understand B cell development and their spatial activity, ultimately applying these insights to clinical scenarios like antibody responses and inflammatory bowel disease.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of diseases related to B cell dysfunction, enhancing patient care.
How similar studies have gone: Other research has shown promise in using advanced sequencing technologies to study immune cells, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Khan, Aly Azeem — University of Chicago
- Study coordinator: Khan, Aly Azeem
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.