Understanding how B cells contribute to food allergies in children
Official title: B cell memory in human food allergy
Funded at Icahn School of Medicine at Mount Sinai · NIH-11091433 · Data updated 2026-11-12
This study is looking at how certain immune cells called B cells and their antibodies affect food allergies in kids, especially why some allergies go away on their own while others stick around, with the hope of finding new ways to help manage these allergies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 9, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $758,401 |
| NIH project number | 5R01AI153708-05 |
| Project ID | NIH-11091433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been diagnosed with food allergies, particularly to peanuts.
✕Less likely to help
Patients who do not have food allergies or are outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research investigates the role of B cells in food allergies, particularly focusing on how certain high affinity IgE antibodies can lead to severe allergic reactions in children. The study aims to uncover why some food allergies resolve on their own while others persist, by examining the memory of B cells that produce these antibodies. Through experimental studies, researchers will analyze the activation and differentiation of B lymphocytes in atopic individuals to understand their contribution to allergic responses. The findings could provide insights into potential therapeutic strategies for managing food allergies in children.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for children suffering from food allergies.
How similar studies have gone: Previous research has shown promising results in understanding the immune mechanisms behind allergies, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Curotto de Lafaille, Maria a — Icahn School of Medicine at Mount Sinai
- Study coordinator: Curotto de Lafaille, Maria a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.