Understanding how B cells behave in the brain during aging and autoimmune diseases
Ontogenetic niche of B cells at the CNS borders in homeostasis, aging and autoimmunity
This study is looking at how certain immune cells called B cells behave in the brain and spinal cord, especially in people with autoimmune diseases like multiple sclerosis and lupus, to help find better ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11009012 on NIH RePORTER |
What this research studies
This research investigates the role of B cells in the central nervous system (CNS) and their involvement in autoimmune disorders like multiple sclerosis and lupus. It aims to understand how these B cells are generated and how they infiltrate the CNS, particularly focusing on the differences between young and aged individuals. The study will explore the origins of meningeal B cells and their potential to become autoreactive, which could lead to better therapeutic strategies for autoimmune conditions. By examining the interactions between B cells and the CNS environment, the research seeks to uncover mechanisms that could inform treatment approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autoimmune neurological disorders, particularly those who are experiencing symptoms related to multiple sclerosis or lupus.
Not a fit: Patients with non-autoimmune neurological conditions or those without any neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from autoimmune diseases affecting the nervous system.
How similar studies have performed: Previous research has shown promising results in understanding B cell behavior in autoimmune diseases, indicating that this approach has the potential for significant insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Colonna, Marco — Washington University
- Study coordinator: Colonna, Marco
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.