Understanding how B cells affect nerve pain after injury
Regulation of Peripheral Neuropathic Pain by B Cells
This study is looking at how certain immune cells called B cells might be involved in keeping nerve pain going after an injury, with the hope of finding new ways to help people who suffer from chronic pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11058366 on NIH RePORTER |
What this research studies
This research investigates the role of B cells in the maintenance of neuropathic pain following peripheral nerve injury. By examining how B cells differentiate and function in response to nerve damage, the study aims to uncover the mechanisms that contribute to chronic pain. The researchers hypothesize that B cells produce autoantibodies that interact with nerve tissues, perpetuating pain signals. Through this work, they hope to identify new therapeutic targets that could modify the immune response and alleviate neuropathic pain for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from neuropathic pain due to peripheral nerve injuries.
Not a fit: Patients with neuropathic pain not related to peripheral nerve injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce or eliminate neuropathic pain for patients.
How similar studies have performed: Previous research has shown promising results in understanding the immune mechanisms involved in neuropathic pain, suggesting that this approach could yield significant insights.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Grace, Peter M — University of Tx Md Anderson Can Ctr
- Study coordinator: Grace, Peter M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.