Understanding how B-cell lymphomas manipulate gene regulation
Official title: Chromunities Drive Transcriptional Reprogramming in Humoral Immunity and B-cell Lymphomas
Funded at Weill Medical Coll of Cornell Univ · NIH-10821323 · Data updated 2026-11-12
This study is looking at how a type of blood cancer called diffuse large B-cell lymphoma starts from normal B-cells and how it tricks the body’s natural controls to help it grow, with the hope of finding new ways to treat it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 21, 2023 |
| Project end | September 20, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31CA271776-02 |
| Project ID | NIH-10821323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with diffuse large B-cell lymphoma or other related B-cell malignancies.
✕Less likely to help
Patients with non-B-cell lymphomas or those without any form of lymphoma may not receive benefit from this research.
What this research studies
This research investigates how diffuse large B-cell lymphomas (DLBCL) arise from B-cells and how these tumors can hijack normal B-cell regulatory mechanisms to promote their growth. The study focuses on the 3D organization of the genome and how changes in this structure can influence gene expression in B-cells. By examining the interactions between regulatory elements and genes, the research aims to uncover the mechanisms that drive the development of these cancers, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with B-cell lymphomas by targeting the underlying mechanisms of gene regulation.
How similar studies have gone: Other research has shown promise in understanding gene regulation in cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Durmaz, Ceyda — Weill Medical Coll of Cornell Univ
- Study coordinator: Durmaz, Ceyda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.