Understanding how axons function in health and disease
The Molecular Architecture of Axons in Health and Disease
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-11083088
This study is looking at how the tiny parts of nerve cells, called axons, work to send signals in the body, especially when they get damaged, and it hopes to find new ways to help heal or fix these nerves for people with nerve injuries or diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11083088 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular structure and function of axons, which are crucial for transmitting signals in the nervous system. It focuses on the axon initial segments and nodes of Ranvier, which are essential for the initiation and propagation of action potentials. By using advanced techniques such as proteomics and genetic manipulation, the study aims to uncover the mechanisms that maintain axonal integrity and how these are disrupted in diseases or injuries. The findings could lead to new therapeutic strategies for repairing or regenerating damaged nervous tissue.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders or injuries that affect axonal function.
Not a fit: Patients with conditions unrelated to axonal dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for neurological disorders by enhancing axonal repair and function.
How similar studies have performed: Previous research has shown promising results in understanding axonal structures and their roles in disease, indicating that this approach has potential for success.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RASBAND, MATTHEW N — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: RASBAND, MATTHEW N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.