Understanding how axons can be protected from degeneration in neurodegenerative diseases
Identifying mechanisms that regulate local axon vulnerability to pathological degeneration
This study is looking into why the connections between nerve cells can break down in diseases like Alzheimer's and hopes to find ways to keep them healthy, which could help develop new treatments for people affected by these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11041153 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that make axons vulnerable to degeneration in neurodegenerative disorders like Alzheimer's disease. It focuses on understanding how axons, which are crucial for neuronal connectivity, can survive damage and what factors influence their health. The study aims to identify new pathways that regulate axon health and explore the role of specific enzymes and cellular processes in protecting axons from degeneration. By uncovering these mechanisms, the research seeks to provide insights that could lead to new therapeutic strategies for patients suffering from neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease.
Not a fit: Patients with acute injuries unrelated to neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect axons and improve outcomes for patients with neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding axonal health and its implications for neurodegenerative diseases, suggesting that this approach has potential for success.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Summers, Daniel — University of Iowa
- Study coordinator: Summers, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.