Understanding how axon structure affects nerve signal transmission
Official title: CRCNS: Biophysical modeling of axonal morphology and function
Funded at University of California, San Diego · NIH-11083186 · Data updated 2026-11-12
This study is looking at how the size of nerve fibers, called axons, can change when neurons are active, which could help us understand how signals travel in the nervous system and how different conditions might affect this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $375,835 |
| NIH project number | 1R01MH139350-01 |
| Project ID | NIH-11083186 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions that affect nerve function or signal transmission.
✕Less likely to help
Patients with purely structural or non-neurological conditions may not receive any benefit from this research.
What this research studies
This research investigates the intricate structure of axons, which are essential for neuron function and communication. It explores how the diameter of axons can change dynamically based on neuronal activity, challenging the traditional view of uniform axon size. By using advanced computer modeling, the study aims to understand how the physical properties of axon membranes influence their shape and function. This could lead to insights into how nerve signals are transmitted and how they can be affected by various conditions.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of nerve signal transmission, potentially leading to improved treatments for neurological disorders.
How similar studies have gone: Other research has shown promising results in understanding axon dynamics and their implications for nerve function, indicating that this approach is building on established findings.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Rangamani, Padmini — University of California, San Diego
- Study coordinator: Rangamani, Padmini
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.