Understanding how autophagy affects gut health and inflammation
Official title: HIF-Regulated Autophagy in Host-microbe Interactions
Funded at VA Eastern Colorado Health Care System · NIH-10951497 · Data updated 2026-11-12
This study is looking at how a natural recycling process in our cells might affect inflammatory bowel disease (IBD) in military veterans, with the hope of finding new treatments to help people dealing with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | October 1, 2023 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 5IK2BX006088-02 |
| Project ID | NIH-10951497 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are military veterans experiencing symptoms of inflammatory bowel disease.
✕Less likely to help
Patients who do not have inflammatory bowel disease or are not military veterans may not benefit from this research.
What this research studies
This research investigates the role of autophagy, a cellular recycling process, in the context of inflammatory bowel disease (IBD), particularly among military veterans. By studying animal models, the research aims to uncover the molecular mechanisms that contribute to IBD and how these processes interact with gut bacteria. The goal is to identify potential new therapies that can improve treatment outcomes for patients suffering from chronic gastrointestinal inflammation.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for inflammatory bowel disease with fewer side effects.
How similar studies have gone: Previous research has shown promising results in understanding autophagy's role in gut health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
VA Eastern Colorado Health Care System
Aurora, United States Active
Researchers
- Principal investigator: Dowdell, Alexander Shea — VA Eastern Colorado Health Care System
- Study coordinator: Dowdell, Alexander Shea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.