Understanding how autonomic nervous system issues affect individuals with fragile X syndrome and premutation.
Autonomic and Sensory Dysfunctions in FMR1 Conditions: Development, Mechanisms and Consequences
This study is looking at how the nervous system works in kids with fragile X syndrome and its premutation, to see when problems start and how they change as they grow, while also checking how genes might affect these issues and their behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11087648 on NIH RePORTER |
What this research studies
This research investigates the role of autonomic nervous system (ANS) dysfunction in individuals with fragile X syndrome (FXS) and fragile X premutation (FXpm). It aims to identify when ANS dysfunction begins and how it develops over time in young children, comparing these findings with typical development. The study will also explore how genetic factors influence ANS dysfunction and its impact on behavior and sensory processing. By following participants over several months, the research seeks to uncover the connections between physiological responses and behavioral challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research include young children diagnosed with fragile X syndrome or fragile X premutation, as well as typical controls for comparison.
Not a fit: Patients without a diagnosis of fragile X syndrome or fragile X premutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and interventions for individuals with fragile X syndrome and premutation, improving their quality of life.
How similar studies have performed: While research on autonomic dysfunction in FXS is limited, similar studies in other conditions have shown promising results, indicating the potential for significant findings in this area.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Roberts, Jane E — University of South Carolina at Columbia
- Study coordinator: Roberts, Jane E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.