Understanding how autoantibodies affect kidney function in membranous nephropathy
Official title: Investigating the functional capacity of autoantibodies in primary membranous nephropathy
Funded at Boston Medical Center · NIH-10667599 · Data updated 2026-11-12
This study is looking at how certain antibodies in the body affect kidney health in people with primary membranous nephropathy, with the hope of finding better ways to treat the disease and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 20, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $262,491 |
| NIH project number | 5R01DK126978-03 |
| Project ID | NIH-10667599 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with primary membranous nephropathy, particularly those experiencing variability in disease severity and treatment response.
✕Less likely to help
Patients with other forms of kidney disease or those who do not have primary membranous nephropathy may not benefit from this research.
What this research studies
This research investigates the role of autoantibodies in primary membranous nephropathy, an autoimmune kidney disease. It aims to identify how these antibodies contribute to kidney injury and the variability in disease outcomes among patients. By developing new assays to measure these autoantibodies, the research seeks to improve treatment decisions and predict patient responses to therapy. The ultimate goal is to enhance the understanding of disease mechanisms and improve patient care.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for patients with membranous nephropathy, potentially improving kidney function and quality of life.
How similar studies have gone: Previous research has shown promise in understanding the role of autoantibodies in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston Medical Center
Boston, United States Active
Researchers
- Principal investigator: Beck, Laurence H — Boston Medical Center
- Study coordinator: Beck, Laurence H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.