Understanding how autism affects brain growth using advanced imaging techniques
Quantifying the developmental trajectory of autism-associated brain overgrowth using 3D cellular resolution imaging
This study looks at how the brains of mice with autism-related genetic changes grow and develop over time, using special imaging techniques to see the differences in brain cells compared to normal mice, which could help us understand more about autism and its effects on brain development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10657348 on NIH RePORTER |
What this research studies
This research investigates the developmental changes in the brains of mice with autism-related genetic mutations. By utilizing advanced imaging technologies, the study aims to capture detailed images of brain cells over time, allowing researchers to observe how these cells develop and change. The focus is on understanding the differences in brain structure between normal mice and those with specific genetic alterations associated with autism. This could provide insights into the biological mechanisms underlying autism and its impact on brain development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autism spectrum disorders, particularly those with known genetic mutations like CHD8.
Not a fit: Patients without autism or those whose conditions are unrelated to the genetic factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of autism and inform future treatments or interventions.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques to study brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Stein, Jason Louis — Univ of North Carolina Chapel Hill
- Study coordinator: Stein, Jason Louis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.