Understanding how auditory neurons develop and function
Mechanisms of Auditory Circuit Development
This study is looking at how certain nerve cells in the ear, which are important for hearing, develop and work together, especially when there are problems with the tiny hair cells that help us hear, to help us understand more about hearing loss and find new ways to improve it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10982485 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that influence the development and function of auditory neurons, specifically spiral ganglion neurons (SGNs), which are crucial for hearing. By using genetically modified mice and advanced techniques like imaging and electrophysiology, the researchers aim to understand how these neurons connect and communicate with hair cells in the ear. The study will explore how defects in hair cells can lead to hearing loss and how different types of SGNs may have unique roles in auditory perception. The ultimate goal is to uncover the biological signals that guide the differentiation and connectivity of these neurons, which could lead to new insights into hearing impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults experiencing age-related hearing loss or auditory processing issues.
Not a fit: Patients with hearing loss due to non-genetic factors or those who do not have auditory neuron involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related hearing loss and other auditory disorders.
How similar studies have performed: Previous research has shown promising results in understanding auditory neuron development, indicating that this approach has potential for significant findings.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Mueller, Ulrich — Johns Hopkins University
- Study coordinator: Mueller, Ulrich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.