Understanding how atypical B cells help fight malaria
The function of atypical B cells in the immune response against malaria
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-11220157
This study is looking at how certain types of B cells in young children help fight off malaria, with the goal of finding ways to make malaria vaccines work better and keep kids safe from this disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11220157 on ClinicalTrials.gov |
What this research studies
This research investigates the role of atypical B cells in the immune response to malaria, particularly in young children. It aims to differentiate between functional and dysfunctional atypical B cells to understand how they contribute to immunity against the Plasmodium parasites that cause malaria. By analyzing the development and function of these B cells, the research seeks to improve malaria vaccine efficacy, which is crucial given the high mortality rates among children. The study will involve examining immune responses in individuals who have experienced malaria to identify potential protective mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been exposed to malaria.
Not a fit: Patients who have not been exposed to malaria or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective malaria vaccines, ultimately reducing the incidence and mortality of malaria in children.
How similar studies have performed: Other research has shown promise in understanding immune responses to malaria, but the specific focus on atypical B cells is a novel approach.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUNNIK, EVELIEN MARGARETHA — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: BUNNIK, EVELIEN MARGARETHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.