Understanding how ATR helps maintain genome stability in cells
Official title: Elucidating how ATR promotes genome stability independent of the DNA damage response pathway
Funded at Yale University · NIH-11092780 · Data updated 2026-11-12
This study is looking at how a protein called ATR helps keep cancer cells stable and healthy, which could lead to better treatments for patients by understanding why some cancers resist drugs and how they grow.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $418,750 |
| NIH project number | 5R35GM150648-03 |
| Project ID | NIH-11092780 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that exhibit drug resistance or those with genetic conditions related to genome instability.
✕Less likely to help
Patients with non-cancerous conditions or those not affected by genome instability may not receive direct benefits from this research.
What this research studies
This research investigates the role of the ATR kinase in maintaining genome stability, particularly in cancer cells. It aims to uncover how ATR functions independently of the DNA damage response pathway, which is crucial for proper cell division and growth. By exploring ATR's involvement in both mitosis and interphase, the research seeks to identify mechanisms that could lead to improved cancer treatments. Patients may benefit from insights gained about drug resistance and cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for overcoming drug resistance in cancer treatment.
How similar studies have gone: Previous research has shown promising results in understanding the roles of DNA damage response pathways in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Kabeche, Lilian Carolina — Yale University
- Study coordinator: Kabeche, Lilian Carolina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.