Understanding how ATP helps immune cells fight viruses
Control of antiviral memory CD8+ T cell longevity by extracellular ATP sensing
['FUNDING_R01'] · MAYO CLINIC ARIZONA · NIH-10864044
This study is looking at how a substance called ATP helps memory T cells, which are important for fighting off viruses like the flu, live longer and work better, so we can improve vaccines and treatments for viral infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ARIZONA (nih funded) |
| Locations | 1 site (SCOTTSDALE, UNITED STATES) |
| Trial ID | NIH-10864044 on ClinicalTrials.gov |
What this research studies
This research investigates the role of extracellular ATP in promoting the longevity of memory CD8+ T cells, which are crucial for controlling viral infections like influenza. By examining how ATP interacts with specific receptors on these immune cells, the study aims to uncover mechanisms that enhance their survival and effectiveness. The research involves both laboratory experiments and analysis of immune responses to viral infections, focusing on how these memory cells can be better harnessed for immunizations and antiviral therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced viral infections, particularly those with a history of influenza.
Not a fit: Patients with non-viral infections or those who do not have a history of viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments that enhance the body's ability to fight viral infections.
How similar studies have performed: Other research has shown promising results in enhancing immune responses through similar mechanisms, indicating potential for success in this approach.
Where this research is happening
SCOTTSDALE, UNITED STATES
- MAYO CLINIC ARIZONA — SCOTTSDALE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BORGES DA SILVA, HENRIQUE — MAYO CLINIC ARIZONA
- Study coordinator: BORGES DA SILVA, HENRIQUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.